Electronic Journal of Differential Equations, Vol. 2000(2000), No. 36, pp. 1-10. Title: Global minimizing domains for the first eigenvalue of an elliptic operator with non-constant coefficients Authors: Dorin Bucur (Univ. de Franche-Comte, France) Nicolas Varchon (Univ. de Franche-Comte, France) Abstract: We consider an elliptic operator, in divergence form, that is a uniformly elliptic matrix. We describe the behavior of every sequence of domains which minimizes the first Dirichlet eigenvalue over a family of fixed measure domains of $R^N$. The existence of minimizers is proved in some particular situations, for example when the operator is periodic. Submitted February 1-st, 2000. Published May 16, 2000. Math Subject Classifications: 49Q10, 49R50. Key Words: First eigenvalue; Dirichlet boundary; non-constant coeffcients; optimal domain.