Electronic Journal of Differential Equations, Vol. 2004(2004), No. 117, pp. 1-6. Title: On the instability of certain sixth-order nonlinear differential equations Author: Cemil Tunc (Yuzuncu Yil Univ., Turkey) Abstract: In this paper, we give an instability criteria for the nonlinear sixth-order vector differential equation $$\displaylines{ X^{(6)} + AX^{(5)} +B(t)\Phi (X,\dot {X},\ddot {X}, X^{(3)},X^{(4)},X^{(5)})X^{(4)} + C(t)\Psi (\ddot {X}),X^{(3)}\cr +D(t)\Omega (X,\dot {X},\ddot {X},X^{(3)},X^{(4)},X^{(5)}) \ddot {X}+E(t)G(\dot {X})+H(X) = 0\,. }$$ The result extends and includes earlier results [6,16,20]. Submitted July 13, 2004. Published October 7, 2004. Math Subject Classifications: 34D05, 34D20. Key Words: Nonlinear differential equations of sixth order; instability; Lyapunov function.