Electronic Journal of Differential Equations, Vol. 2005(2005), No. 116, pp. 1-43. Title: Pseudodifferential operators with generalized symbols and regularity theory Authors: Claudia Garetto (Univ. Innsbruck, Austria) Todor Gramchev (Univ. di Cagliari, Italy) Michael Oberguggenberger (Univ. Innsbruck, Austria) Abstract: We study pseudodifferential operators with amplitudes $a_\varepsilon (x,\xi)$ depending on a singular parameter $\varepsilon \to 0$ with asymptotic properties measured by different scales. We prove, taking into account the asymptotic behavior for $\varepsilon \to 0$, refined versions of estimates for classical pseudodifferential operators. We apply these estimates to nets of regularizations of exotic operators as well as operators with amplitudes of low regularity, providing a unified method for treating both classes. Further, we develop a full symbolic calculus for pseudodifferential operators acting on algebras of Colombeau generalized functions. As an application, we formulate a sufficient condition of hypoellipticity in this setting, which leads to regularity results for generalized pseudodifferential equations. Submitted June 13, 2005. Published October 21, 2005. Math Subject Classifications: 35S50, 35S30, 46F10, 46F30, 35D10. Key Words: Pseudodifferential operators; small parameter; slow scale net; algebras of generalized functions.