Electronic Journal of Differential Equations, Vol. 2007(2007), No. 04, pp. 1-11. Title: Global well-posedness of the Cauchy problem of a higher-order Schrodinger equation Author: Hua Wang (Sun Yat-Sen Univ., Guangzhou, China) Abstract: We apply the I-method to prove that the Cauchy problem of a higher-order Schrodinger equation is globally well-posed in the Sobolev space $H^{s}(\mathbb{R})$ with s>6/7. Submitted September 7, 2006. Published January 2, 2007. Math Subject Classifications: 35Q53, 35Q35. Key Words: Higher order Schrodinger equation; global well-posedness; I-method.