Electronic Journal of Differential Equations, Vol. 2007(2007), No. 56, pp. 1-21. Title: Boundary-value problems for second-order differential operators with nonlocal boundary conditions Authors: Mohamed Denche (Univ. Mentouri, Algeria) Abderrahmane Meziani (Univ. Mentouri, Algeria) Abstract: In this paper, we study a second-order differential operator combining weighting integral boundary condition with another two-point boundary condition. Under certain conditions on the weighting functions, called regular and non regular cases, we prove that the resolvent decreases with respect to the spectral parameter in $L^{p}(0,1)$, but there is no maximal decrease at infinity for $p>1$. Furthermore, the studied operator generates in $L^{p}(0,1) $, an analytic semi group for $p=1$ in the regular case, and an analytic semi group with singularities for $p>1$, in both cases, and for $p=1$, in the non regular case only. The obtained results are then used to show the correct solvability of a mixed problem for parabolic partial differential equation with non regular boundary conditions. Submitted May 10, 2006. Published April 17, 2007. Math Subject Classifications: 47E05, 35K20. Key Words: Green's function; regular and non regular boundary conditions; semi group with singularities; weighted mixed boundary conditions.