\documentclass[reqno]{amsart}
\usepackage{hyperref}

\AtBeginDocument{{\noindent\small
\emph{Electronic Journal of Differential Equations},
Vol. 2014 (2014), No. 130, pp. 1--13.\newline
ISSN: 1072-6691. URL: http://ejde.math.txstate.edu or http://ejde.math.unt.edu
\newline ftp ejde.math.txstate.edu}
\thanks{\copyright 2014 Texas State University - San Marcos.}
\vspace{9mm}}

\begin{document}
\title[\hfilneg EJDE-2014/130\hfil Uniqueness and existence of positive solutions]
{Uniqueness and existence of positive solutions for singular fractional
differential equations}

\author[N. Nyamoradi, T. Bashiri, S. M. Vaezpour, D. Baleanu 
 \hfil EJDE-2014/??\hfilneg]
{Nemat Nyamoradi, Tahereh Bashiri, \\
S. Mansour Vaezpour, Dumitru Baleanu}  

\address{Nemat Nyamoradi \newline
Department of Mathematics, Faculty of Sciences, Razi University,
67149 Kermanshah, Iran}
\email{nyamoradi@razi.ac.ir}

\address{Tahereh Bashiri \newline
Department of Mathematics and Computer Sciences,
Amirkabir University of Technology, Tehran, Iran}
\email{t.bashiri@aut.ac.ir}

\address{S. Mansour Vaezpour \newline
Department of Mathematics and Computer Sciences,
Amirkabir University of Technology, Tehran, Iran}
\email{vaez@aut.ac.ir}

\address{Dumitru Baleanu \newline
Department of Mathematics and Computer Sciences, Faculty of Art and Sciences,
Cankaya University, 06530 Ankara, Turkey.\newline
Institute of Space Sciences, P.O.BOX, MG-23,
R 76900,Magurele-Bucharest, Romania.\newline
Department of Chemical and Materials
Engineering, Faculty of Engineering,
King Abdulaziz University, P.O. Box 80204, Jeddah
21589, Saudi Arabia}
\email{dumitru@cankaya.edu.tr}


\thanks{Submitted August 21, 2013. Published June 6, 2014.}
\subjclass[2000]{34A08, 74H20,30E25}
\keywords{Existence of solutions; Banach’s fixed
point theorem; \hfill\break\indent Leray-Schauder’s alternative}

\begin{abstract}
 In this article, we study the existence of positive solutions for the
 singular fractional boundary value problem
 \begin{gather*}
 - D^\alpha u(t) = A f (t, u (t))+\sum_{i=1}^k B_i I^{\beta_i} g_i (t, u(t)) ,
    \quad    t \in (0, 1),\\
 D^\delta u (0) = 0,\quad D^\delta u (1)
    = a D^{\frac{\alpha-\delta-1}{2}}(D^\delta u (t))\big|_{t=\xi}
 \end{gather*}
 where $1<\alpha\leq 2$, $0<\xi \leq 1/2$, $a \in [0,\infty)$, $1<\alpha-\delta <2$,
 $0<\beta_i< 1$, $A,B_i$, $1\leq i \leq k$, are real constant, $D^\alpha$
 is the Riemann-Liouville fractional derivative of order $\alpha$.
 By using the Banach's fixed point theorem and Leray-Schauder's alternative, the
 existence  of positive solutions is obtained. At last, an
 example is given for illustration.
\end{abstract}

\maketitle
\numberwithin{equation}{section}
\newtheorem{theorem}{Theorem}[section]
\newtheorem{lemma}[theorem]{Lemma}
\newtheorem{example}[theorem]{Example}
\newtheorem{definition}[theorem]{Definition}
\allowdisplaybreaks


\section{Introduction}

Fractional calculus is the field of
mathematical analysis which deals with the investigation and
applications of integrals and derivatives of arbitrary order, the
fractional calculus may be considered an old and yet novel topic.

Recently, fractional differential equations have been of great
interest. This is because of both the intensive development of the
theory of fractional calculus itself and its applications in
various sciences, such as physics, mechanics, chemistry,
engineering, etc. For example, for fractional initial value
problems, the existence and multiplicity of solutions were
discussed in \cite{Babakhani,Delbosco,Kilbas1,Kilbas2},
moreover, fractional derivative arises from many physical
processes,such as a charge transport in amorphous semiconductors
\cite{Scher}, electrochemistry and material science are also
described by differential equations of fractional order 
\cite{Diethelm,Gaul,Glockle,Mainardi,Metzler}. 
 Bai and L\"{u} \cite{Bai} considered the boundary value
problem of fractional order differential equation
\begin{gather*}
    D_{0^+}^\alpha u(t) + f (t, u (t))=0,
    \quad    t \in (0, 1),\\
    u(0)=  u(1)=0,
\end{gather*}
where  $D_{0^+}^\alpha$ is the standard Riemann-Liouville
fractional derivative of order
$1<\alpha \leq 2$ and\\ $f:[0,1]\times [0, \infty)\to [0,\infty)$
is continuous.

 Hussein \cite{Hussein}, considered the
following nonlinear $m$-point boundary value problem of fractional
type
\begin{gather*}
    D_{0^+}^\alpha x (t)+ q(t) f (t, x (t))=0,
    \quad  \text{a.e.  on }[0, 1],\alpha \in (n-1,n], n\geq 2,\\
x(0)=  x'(0)=x''(0)=\dots=x^{(n-2)} (0)=0,\quad
x(1)= \sum_{i=1}^{m-2} \xi_i x (\eta_i),
\end{gather*}
where $ 0<\eta_1<\dots<\eta_{m-2}<1,\xi_i>0 $ with
$\sum_{i=1}^{m-2} \xi_i \eta_i^{\alpha-1}<1$, $q$ is a
real-valued
continuous function and $f$ is a nonlinear Pettis integrable function.

Motivated by the above works, the purpose of this paper is to
discuss the following singular fractional boundary value problem:
\begin{equation}\label{1}
\begin{gathered}
    - D^\alpha u(t) = A f (t, u (t))+\sum_{i=1}^k B_i I^{\beta_i} g_i (t, u(t)) ,
    \quad    t \in (0, 1),\\
    D^\delta u (0) = 0,\quad  
D^\delta u (1) = a D^{\frac{\alpha-\delta-1}{2}}(D^\delta u(t))\big|_{t=\xi},
\end{gathered}
\end{equation}
where $1<\alpha\leq 2$, $0<\xi \leq \frac{1}{2} $, 
$a \in (0, \infty)$, $1<\alpha-\delta <2$, $0<\beta_i< 1$, $A,B_i$, 
$1\leq i \leq k$, are real constant, $D^\alpha$ is the
Riemann-Liouville fractional derivative of order $\alpha$.

The rest of this paper is organized as follows. In Section 2, we
give some preliminaries. In Sections 3 and 4, we study the
existence and uniqueness of solutions for system \eqref{1} by
Banach's fixed point theorem and Leray-Schauder's alternative,
respectively. At last, in Section 5, an example is also given to
illustrate our theory.

\section{Preliminaries}

In this section, we present 
notation and some preliminary lemmas that will be used in the proofs
of the main results.

\begin{definition}[\cite{Podlubny,Samko}] \rm
The Riemann-Liouville fractional integral operator of order
$\alpha > 0$, of function $f \in L^1(\mathbb{R}^+)$ is defined as
\[
I_{0^+}^\alpha f(t) = \frac{1}{\Gamma (\alpha)} \int_0^t (t -
s)^{\alpha - 1} f (s) d s,
\]
where $\Gamma  (\cdot)$ is the Euler gamma function.
\end{definition}

\begin{definition}[\cite{Podlubny,Samko}] \rm
The Riemann-Liouville fractional derivative of order $\alpha > 0$
of a continuous function $f:(0,\infty)\to\mathbb{R}$ is
defined as
\[
D_{0^+}^\alpha f(t) = \frac{1}{\Gamma (n - \alpha)}
\Big(\frac{d}{dt}\Big)^n \int_0^t (t - s)^{n - \alpha - 1} f (s) ds,
\]
where $n=[\alpha]+1$.
\end{definition}

\begin{lemma}[\cite{Kilbas3}] \label{lem1}
 The equality $D_{0^+}^\gamma I_{0^+}^\gamma
f(t) = f(t)$ with $\gamma > 0$ holds for $f \in L^1 (0, 1)$.
\end{lemma}

\begin{lemma}[\cite{Kilbas3}] \label{lem2}
Let $\alpha > 0$. Then the differential equation
\begin{align*}
D_{0^+}^\alpha u = 0
\end{align*}
has a unique solution $u (t) = c_1 t^{\alpha - 1} + c_2 t^{\alpha
- 2} + \dots + c_n t^{\alpha - n}$, $c_i \in \mathbb{R}$, 
$i = 1, \dots, n$, there $n - 1 < \alpha \leq n$.
\end{lemma}

\begin{lemma}[\cite{Kilbas3}]\label{lem3}
Let $\alpha > 0$. Then the following
equality holds for $u \in L^1 (0, 1)$, 
$D_{0^+}^\alpha u \in L^1 (0, 1)$;
\begin{align*}
I_{0^+}^\alpha D_{0^+}^\alpha u (t) = u (t) + c_1 t^{\alpha - 1} +
c_2 t^{\alpha - 2} + \dots + c_n t^{\alpha - n},
\end{align*}
$c_i \in \mathbb{R}$, $i = 1, \dots, n$, there $n - 1 < \alpha
\leq n$.
\end{lemma}

\begin{lemma}[\cite{Bai}]\label{Re}
For $\lambda>-1$ and $\alpha>0$,
\[
D_{0^+}^\alpha  t^\gamma = \frac{\Gamma (\gamma+1)}{\Gamma (\gamma
- \alpha+1)}t^{\gamma-\alpha}.
\]
\end{lemma}
\begin{lemma}[\cite{Li}]\label{pii}
Suppose that $g \in L^1(0,1)$ and $\alpha,\beta$
be two constant such that $0\leq \beta \leq 1 <\alpha$, then
\[
D_{0^+}^\beta \int_0^t  (t-s)^{\alpha-1} g(s) ds= \frac{\Gamma
(\alpha)}{\Gamma (\alpha - \beta)}\int_0^t  (t-s)^{\alpha-\beta-1}
g(s)\, ds.
\]
\end{lemma}

Now, we consider \eqref{1}. By the substitution
$u(t)=I^\delta y(t)=D^{-\delta} y(t)$,  problem \eqref{1} is
turned into 
\begin{equation}\label{222}
\begin{gathered}
    - D^{\alpha - \delta} y(t) = A f (t, I^\delta y(t))+\sum_{i=1}^k B_i I^{\beta_i} g_i (t, I^\delta y(t)) ,
    \quad    t \in (0, 1),\\
    y (0) = 0,\quad y (1) = a
    D^{\frac{\alpha-\delta-1}{2}}y(t))\big|_{t=\xi}.
\end{gathered}
\end{equation}


\begin{lemma}\label{b}
For any $h\in C[0,1]\cap L(0,1)$, the unique solution of the
boundary value problem
\begin{equation}\label{333}
\begin{gathered}
    - D^{\alpha - \delta} y(t)=h(t) ,
    \quad    t \in (0, 1),\\
    y (0) = 0,\quad  y (1) = a D^{\frac{\alpha-\delta-1}{2}}y(t))\big|_{t=\xi}
\end{gathered}
\end{equation}
is
\[
y(t)=- I^{\alpha-\delta} h(t)+\frac{t^{\alpha-\delta-1}
\Gamma(\frac{\alpha-\delta+1}{2})}{\Gamma(\frac{\alpha-\delta+1}{2})
-a\Gamma(\alpha-\delta)\xi^{\frac{\alpha-\delta-1}{2}}}\Big(I^{\alpha-\delta}
h(1) -a I^{\frac{\alpha-\delta+1}{2}} h(\xi)\Big).
\]
\end{lemma}

\begin{proof}
 By applying Lemma \ref{lem3},  equation
\eqref{333} is equivalent to the  integral equation
\begin{equation}\label{s'}
y(t) =  - I^{\alpha-\delta} h(t) -  c_1 
t^{\alpha-\delta  - 1}  -  c_2 
t^{\alpha-\delta  - 2},
\end{equation}
for some arbitrary constants $c_1,c_2\in\mathbb{R}$.

By the boundary condition $y(0)=0$, we conclude that $c_2=0$.
Then, we have
\[
y(1) =  - I^{\alpha-\delta} h(1) -  c_1,
\]
and it follows from lemma \eqref{Re} that
\begin{align*}
D^{\frac{\alpha-\delta-1}{2}}y(t) 
&= -D^{\frac{\alpha-\delta-1}{2}} I^{\alpha-\delta} h(t) - 
c_1
D^{\frac{\alpha-\delta-1}{2}} t^{\alpha-\delta-1}\\
&=  -I^{\frac{\alpha-\delta+1}{2}}h(t)-c_1
\frac{\Gamma(\alpha-\delta)}{\Gamma(\frac{\alpha-\delta+1}{2})}t^{\frac{\alpha-\delta-1}{2}}.
\end{align*}
Therefore,
\[
D^{\frac{\alpha-\delta-1}{2}}y(t)\Big|_{t=\xi}
= -\int_0 ^{\xi} \frac{(\xi-s)^{\frac{\alpha-\delta-1}{2}}}
{\Gamma(\frac{\alpha-\delta+1}{2})}h(s)ds
-c_1 \frac{\Gamma(\alpha-\delta)}{\Gamma(\frac{\alpha-\delta+1}{2})}
t^{\frac{\alpha-\delta-1}{2}}.
\]
So, by the boundary condition $ y (1) = a
D^{\frac{\alpha-\delta-1}{2}}y(t))\big|_{t=\xi}$, we obtain that
\begin{align*}
c_1&=
\frac{\Gamma(\frac{\alpha-\delta+1}{2})}{\Gamma(\frac{\alpha-\delta+1}{2})
-a\Gamma(\alpha-\delta)\xi^{\frac{\alpha-\delta-1}{2}}}\Big[-\int_0^1
\frac{(1-s)^{\alpha-\delta-1}}{\Gamma(\alpha-\delta)} h(s) ds\\
&\quad + a \int_0^\xi
\frac{(\xi-s)^{\frac{\alpha-\delta-1}{2}}}{\Gamma(\frac{\alpha-\delta+1}{2})}
h(s) ds \Big].
\end{align*}
Therefore, the unique solution of equation \eqref{333} is 
  \begin{align*}
y(t)&=- I^{\alpha-\delta} h(t)+\frac{t^{\alpha-\delta-1}
\Gamma(\frac{\alpha-\delta+1}{2})}{\Gamma(\frac{\alpha-\delta+1}{2})-a\Gamma(\alpha-\delta)\xi^{\frac{\alpha-\delta-1}{2}}}\Big[\int_0^1
\frac{(1-s)^{\alpha-\delta-1}}{\Gamma(\alpha-\delta)} h(s) ds\\
&\quad -a \int_0^\xi
\frac{(\xi-s)^{\frac{\alpha-\delta-1}{2}}}{\Gamma(\frac{\alpha-\delta+1}{2})}
h(s) ds \Big].
\end{align*}
The proof is complete. 
\end{proof}

Thus, the solution of the problem  \eqref{1} can be written as
\begin{align*}
u(t)&=  I^{\delta} y(t)\\
&= I^{\delta} \Big[- I^{\alpha-\delta}
h(t)+\frac{t^{\alpha-\delta-1}
\Gamma(\frac{\alpha-\delta+1}{2})}{\Gamma(\frac{\alpha-\delta+1}{2})
-a\Gamma(\alpha-\delta)\xi^{\frac{\alpha-\delta-1}{2}}}\Big(I^{\alpha-\delta}
h(1) -a I^{\frac{\alpha-\delta+1}{2}} h(\xi)\Big)\Big]\\
&=  -I^{\alpha} h(t)+\frac{
\Gamma(\frac{\alpha-\delta+1}{2})}{\Gamma(\frac{\alpha-\delta+1}{2})
-a\Gamma(\alpha-\delta)\xi^{\frac{\alpha-\delta-1}{2}}}\Big(I^{\alpha-\delta}
h(1) -a I^{\frac{\alpha-\delta+1}{2}} h(\xi)\Big)\\
&\quad\times \int_0^t\frac{(t-s)^{\delta-1}}{\Gamma(\delta)}s^{\alpha-\delta-1}ds 
\\
&=  -I^{\alpha} h(t)+\frac{
\Gamma(\frac{\alpha-\delta+1}{2})}{\Gamma(\frac{\alpha-\delta+1}{2})-a\Gamma(\alpha-\delta)\xi^{\frac{\alpha-\delta-1}{2}}}\Big(I^{\alpha-\delta}
h(1) -a I^{\frac{\alpha-\delta+1}{2}} h(\xi)\Big) \\
&\quad\times  \Big\{\frac{t^{\alpha-1}}{\Gamma(\delta)}\int_0^1
(1-\nu)^{\delta-1}\nu^{\alpha-\delta-1}d\nu \Big\},
\end{align*}
where we have used the substitution $s=t\nu$ in the integral of
the last term. Using the relation for the Beta function $B(\cdot, \cdot)$,
$$
B(\alpha,\beta)=\int_0^1 (1-u)^{\alpha-1} u^{\beta-1}
du=\frac{\Gamma(\alpha)\Gamma(\beta)}{\Gamma(\alpha+\beta)},
$$ 
one has
\begin{equation}\label{444}
u(t)=-I^{\alpha} h(t)+\frac{t^{\alpha-1}\Gamma(\alpha-\delta)
\Gamma(\frac{\alpha-\delta+1}{2})}{\Gamma(\alpha)
\Big(\Gamma(\frac{\alpha-\delta+1}{2})-a\Gamma(\alpha-\delta)
\xi^{\frac{\alpha-\delta-1}{2}}\Big)}\Big(I^{\alpha-\delta}
h(1) -a I^{\frac{\alpha-\delta+1}{2}} h(\xi)\Big).
\end{equation}

The solution of the original nonlinear problem \eqref{1} can be
obtained by replacing $h$ with the right hand side of the
fractional equation of \eqref{1}  in \eqref{444}.

The basic space used in this paper is the real Banach space
$\mathcal{C} = C([0, 1], \mathbb{R})$ of all continuous functions
from $[0,1]\to \mathbb{R}$ endowed with the norm $\|u\| =
\sup_{t \in [0,1]}|u(t)|$.

In relation to problem \eqref{1}, we define an operator
$\mathcal{T}:\mathcal{C}\to \mathcal{C}$ as
\begin{align*}
(\mathcal{T}u)(t)
&= - A \int_0^t \frac{{(t-s)}^{\alpha - 1}}
{\Gamma (\alpha )} f(s,u(s))ds  - \sum_{i = 1}^{k} { B_{i} }
\int_0^{t}
\frac{(t-s)^{\alpha+\beta_i - 1}}{\Gamma( \alpha+\beta_i)} g_i(s,u(s))ds \\
&\quad + t^{\alpha-1} A_0 \Big[ A \int_0^1
\frac{{(1-s)}^{\alpha-\delta - 1}} {\Gamma (\alpha-\delta )}
f(s,u(s))ds \\
&\quad +\sum_{i = 1}^{k} { B_{i} } \int_0^{1}
\frac{(1-s)^{\alpha-\delta +\beta_i - 1}}{\Gamma( \alpha-\delta
+\beta_i)} g_i(s,u(s))ds\\
&\quad -a A \int_0^\xi \frac{(\xi-s)^{\frac{\alpha-\delta-1}{2}}}
{\Gamma (\frac{\alpha-\delta+1}{2} )} f(s,u(s))ds  \\
&\quad - a \sum_{i =1}^{k} { B_{i} } \int_0^{\xi}
\frac{(\xi-s)^{\frac{\alpha-\delta-1}{2}+\beta_i}}{\Gamma(
\frac{\alpha-\delta+1}{2}+\beta_i)} g_i(s,u(s))ds \Big],
\end{align*}
where
$$
A_0=\frac{\Gamma(\alpha-\delta)
\Gamma(\frac{\alpha-\delta+1}{2})}{\Gamma(\alpha)
\Big(\Gamma(\frac{\alpha-\delta+1}{2})
-a\Gamma(\alpha-\delta)\xi^{\frac{\alpha-\delta-1}{2}}\Big)}.
$$
  It is clear that the existence of a positive solution for the system \eqref{1} 
is equivalent to the existence of a nontrivial
fixed point of $\mathcal{T}$ on $\mathcal{C}$.

For convenience of the reader, we set
\begin{equation}\label{555}
\begin{aligned}
\Delta
&= \sup_{t\in [0,1]} \Big\{ |A|\Big[ \frac{{t}^{\alpha}}
{\Gamma (\alpha+1 )}+ | A_0|t^{\alpha-1}\Big( \frac{1} {\Gamma
(\alpha-\delta+1 )}+ a \frac{\xi^{\frac{\alpha-\delta+1}{2}}}
{\Gamma (\frac{\alpha-\delta+1}{2}+1 )} \Big) \Big]\\
&\quad +
\sum_{i = 1}^{k} {| B_{i}| }\Big[
\frac{t^{\alpha+\beta_i}}{\Gamma( \alpha+\beta_i+1)}  +|A_0|
t^{\alpha-1}  \Big(\frac{1}{\Gamma( \alpha-\delta +\beta_i+1)}\\
&\quad + a \frac{\xi^{\frac{\alpha-\delta+1}{2}+\beta_i}}{\Gamma(
\frac{\alpha-\delta+1}{2}+\beta_i+1)}\Big)\Big]\Big\}.
\end{aligned}
\end{equation}

\section{Existence results via Banach's fixed point theorem}

In this section, by using Banach's fixed point theorem, we will
establish  find a unique solution of problem \eqref{1}.
Now, we state our results.

\begin{theorem}\label{thm1}
Assume that $f,g_i:[0,1]\times \mathbb{R}\to
\mathbb{R},i=1,\dots,k$, are continuous functions satisfying the
 condition
\begin{itemize}
\item[(A1)] $ |f(t,u)-f(t,v)|\leq L_1 |u-v|$, $|g_i(t,u)-g_i(t,v)|\leq
L_{i+1} |u-v|$, for $i=1,\dots,k$, $t \in [0,1]$, $L_i
>0,(i=1,\dots,k+1) $, $u,v \in \mathbb{R}$.
\end{itemize}
Then the boundary-value problem \eqref{1} has a unique solution if
$L< \frac{1}{\Delta}$, where $L=\max\{L_i: i=1,\dots,k+1\}$ and
$\Delta$ is given by  \eqref{555}.
\end{theorem}

\begin{proof}
 Assume that $M=\max\{M_i:i=1,\dots,k+1\}$, where
$M_i$ are finite numbers given by $\sup_{t\in[0,1]}|f(t,0)|=M_1$,
$\sup_{t\in[0,1]}|g_i(t,0)|=M_{i+1}$. Selecting 
$r> \frac{\Delta M}{1-L\Delta}$, we show that $\mathcal{T}B_r \subset B_r$, where
$B_r= \{u \in \mathcal{C}:\|u\|\leq r\}$. Using that
$|f(s,u(s))|\leq |f(s,u(s))-f(s,0)|+|f(s,0)| \leq L_1 r+M_1$,
$|g_i(s,u(s))|\leq |g_i(s,u(s))-g_i(s,0)|+|g_i(s,0)| \leq L_{i+1}
r+M_{i+1},i=1,\dots,k$, for $u \in B_r$, and \eqref{555} we can
show that
\begin{align*}
& \|(\mathcal{T}u)\|\\
&\leq (Lr+M) \sup_{t\in [0,1]} \Big\{ |A|\Big[
\frac{{t}^{\alpha}} {\Gamma (\alpha+1 )}+ | A_0|t^{\alpha-1}\Big(
\frac{1} {\Gamma (\alpha-\delta+1 )}+ a
\frac{\xi^{\frac{\alpha-\delta+1}{2}}} {\Gamma
(\frac{\alpha-\delta+1}{2}+1 )} \Big) \Big]\\
&\quad + \sum_{i = 1}^{k} {| B_{i}| }\Big[
\frac{t^{\alpha+\beta_i}}{\Gamma( \alpha+\beta_i+1)}  +|A_0|
t^{\alpha-1}  \Big(\frac{1}{\Gamma( \alpha-\delta +\beta_i+1)}\\
&\quad + a\frac{\xi^{\frac{\alpha-\delta+1}{2}+\beta_i}}{\Gamma(
\frac{\alpha-\delta+1}{2}+\beta_i+1)}\Big)\Big]\Big\}\\
&\leq (Lr+M)\Delta < r,
\end{align*}
which implies that $\mathcal{T}B_r \subset B_r$. Now, for 
$u,v\in \mathcal{C}$ we obtain
\begin{align*}
&\|\mathcal{T}u-\mathcal{T}v\|\\
&\leq \sup_{t\in[0,1]} \Big\{|A|\int_0^t \frac{{(t-s)}^{\alpha -
1}} {\Gamma (\alpha )} |f(s,u(s))-f(s,v(s))|ds  \\&\quad +
\sum_{i = 1}^{k} { |B_{i}| } \int_0^{t}
\frac{(t-s)^{\alpha+\beta_i - 1}}{\Gamma( \alpha+\beta_i)} |g_i(s,u(s))-g_i(s,v(s))|ds \\
&\quad +  |A_0|t^{\alpha-1}\Big[ |A| \int_0^1
\frac{{(1-s)}^{\alpha-\delta - 1}} {\Gamma (\alpha-\delta )}
|f(s,u(s))-f(s,v(s))| ds
\\
&\quad+\sum_{i = 1}^{k} {| B_{i}| } \int_0^{1}
\frac{(1-s)^{\alpha-\delta +\beta_i - 1}}{\Gamma( \alpha-\delta
+\beta_i)} |g_i(s,u(s))-g_i(s,v(s))| ds \\
&\quad +|A|a  \int_0^\xi
\frac{(\xi-s)^{\frac{\alpha-\delta-1}{2}}} {\Gamma
(\frac{\alpha-\delta+1}{2} )}|f(s,u(s))-f(s,v(s))|ds
\\
&\quad +a \sum_{i = 1}^{k} { |B_{i}| } \int_0^{\xi}
\frac{(\xi-s)^{\frac{\alpha-\delta-1}{2}+\beta_i-1}}{\Gamma(
\frac{\alpha-\delta-1}{2}+\beta_i)} |g_i(s,u(s))-g_i(s,v(s))| ds
\Big]\Big\}\\
&\leq L \sup_{t\in [0,1]} \Big\{ |A|\Big[ \frac{{t}^{\alpha}}
{\Gamma (\alpha+1 )}+ | A_0|t^{\alpha-1}\Big( \frac{1} {\Gamma
(\alpha-\delta+1 )}+ a \frac{\xi^{\frac{\alpha-\delta+1}{2}}}
{\Gamma (\frac{\alpha-\delta+1}{2}+1 )} \Big)
\Big]\\
&\quad + \sum_{i = 1}^{k} {| B_{i}| }\Big[
\frac{t^{\alpha+\beta_i}}{\Gamma( \alpha+\beta_i+1)}  +|A_0|
t^{\alpha-1}  \Big(\frac{1}{\Gamma( \alpha-\delta +\beta_i+1)}\\
&\quad + a\frac{\xi^{\frac{\alpha-\delta+1}{2}+\beta_i}}{\Gamma(
\frac{\alpha-\delta+1}{2}+\beta_i+1)}\Big)\Big]\Big\}
\|u-v\|\\
&=L \Delta  \|u-v\|.
\end{align*}
By the assumption, $L< 1/\Delta$. Therefore, $\mathcal{T}$
is a contraction. Thus, by the contraction mapping principle
(Banach's fixed point theorem) the proof is complete.
\end{proof}

Now we present another variant of existence uniqueness result
based on the H\"{o}lder inequality.

\begin{theorem}\label{thm2}
Suppose that the continuous functions $f,g_i$ satisfy the
following conditions:
\begin{itemize}
\item[(A2)] $|f(t,u(t))-f(t,v(t))|\leq m(t)
|u-v|,|g_i(t,u(t))-g_i(t,v(t))|\leq n_i(t) |u-v|$, for $t\in
[0,1]$, $u,v\in \mathbb{R}$, $m,n_i\in
L^{\frac{1}{\gamma}}([0,1], \mathbb{R}^{+}), i=1,\dots,k$, and 
$\gamma\in (0,\alpha-\delta-2)$.

\item[(A3)] $|A| \|m\| Z_1 + \sum_{i = 1}^{k} { |B_{i}| } \|n_i\|
Z_{i+1}<1$, where
\begin{align*}
Z_1&=\frac{1}{\Gamma(\alpha)}\Big(\frac{1-\gamma}{\alpha-\gamma}\Big)^{1-\gamma}+
\frac{ |A_0|}{\Gamma (\alpha-\delta )}
\Big(\frac{1-\gamma}{\alpha-\delta -\gamma}\Big)^{1-\gamma}\\
&\quad +\frac{a  |A_0|}{\Gamma (\frac{\alpha-\delta+1}{2}
)}\Big(\frac{1-\gamma}{\frac{\alpha-\delta+1}{2}-\gamma}\Big)^{1-\gamma}
\xi^{\frac{\alpha-\delta+1}{2}-\gamma},
\end{align*}
\begin{align*}
Z_{i+1}&= (\frac{1}{\Gamma( \alpha+\beta_i)})
\Big(\frac{1-\gamma}{\alpha+\beta_i -\gamma}\Big)^{1-\gamma}+
(\frac{|A_0|}{\Gamma( \alpha-\delta+\beta_i)})
\Big(\frac{1-\gamma}{\alpha-\delta +\beta_i
-\gamma}\Big)^{1-\gamma}\\
&\quad+ (\frac{a|A_0|}{\Gamma( \frac{\alpha-\delta+1}{2}+\beta_i)})
\Big(\frac{1-\gamma}{{\frac{\alpha-\delta+1}{2}}+\beta_i-\gamma}\Big)^{1-\gamma}
\xi^{\frac{\alpha-\delta+1}{2}+\beta_i-\gamma},\;\;(i=1,\dots,k),
\end{align*}
and $\|\mu\|=(\int_0^1 |\mu(s)|^{\frac{1}{\gamma}}ds )^{\gamma},
\mu=m,n$.
\end{itemize}
 Then, the boundary value problem \eqref{1} has a unique solution.
\end{theorem}

\begin{proof} 
For $u,v\in \mathbb{R}$ and $t\in[0,1]$, by
H\"{o}lder inequality, we have
\begin{align*}
&\|\mathcal{T}u-\mathcal{T}v\|\\
&\leq  \sup_{t\in[0,1]} \Big\{|A|\int_0^t \frac{{(t-s)}^{\alpha -
1}} {\Gamma (\alpha )} m(s)|u(s)-v(s)|ds
\\
&\quad + \sum_{i = 1}^{k} { |B_{i}| } \int_0^{t}
\frac{(t-s)^{\alpha+\beta_i - 1}}{\Gamma( \alpha+\beta_i)} n_i(s)|u(s)-v(s))|ds \\
&\quad  +  |A_0|\Big[ |A| \int_0^1
\frac{{(1-s)}^{\alpha-\delta - 1}} {\Gamma (\alpha-\delta )}
m(s)|u(s)-v(s)| ds
\\
&\quad +\sum_{i = 1}^{k} {| B_{i}| } \int_0^{1}
\frac{(1-s)^{\alpha-\delta +\beta_i - 1}}{\Gamma( \alpha-\delta
+\beta_i)} n_i(s)|u(s)-v(s))| ds \\
&\quad  +a|A|  \int_0^\xi
\frac{(\xi-s)^{\frac{\alpha-\delta-1}{2}}} {\Gamma
(\frac{\alpha-\delta+1}{2} )} m(s)|u(s)-v(s)|ds
\\
&\quad +a \sum_{i = 1}^{k} { |B_{i}| } \int_0^{\xi}
\frac{(\xi-s)^{\frac{\alpha-\delta-1}{2}+\beta_i}}{\Gamma(
\frac{\alpha-\delta+1}{2}+\beta_i)} n_i(s)|u(s)-v(s))| ds
\Big]\Big\}\\
&\leq  \sup_{t\in[0,1]}
\Big\{\frac{|A|\|m\|}{\Gamma(\alpha)}
 \Big(\frac{1-\gamma}{\alpha-\gamma}\Big)^{1-\gamma}
t^{\alpha-\gamma} + \sum_{i = 1}^{k}(\frac{ { |B_{i}|
}\|n_i\|}{\Gamma( \alpha+\beta_i)})
\Big(\frac{1-\gamma}{\alpha+\beta_i -\gamma}\Big)^{1-\gamma}
t^{\alpha+\beta_i-\gamma} \\
&\quad  +  |A_0|\Big[ \frac{ |A|\|m\|}{\Gamma (\alpha-\delta
)} \Big(\frac{1-\gamma}{\alpha-\delta -\gamma}\Big)^{1-\gamma} +
\sum_{i = 1}^{k}(\frac{ { |B_{i}| }\|n_i\|}{\Gamma(
\alpha-\delta+\beta_i)}) \Big(\frac{1-\gamma}{\alpha-\delta
+\beta_i
-\gamma}\Big)^{1-\gamma}\\
&\quad  +\frac{a |A|\|m\|}{\Gamma (\frac{\alpha-\delta+1}{2}
)}\Big(\frac{1-\gamma}{\frac{\alpha-\delta+1}{2}-\gamma}\Big)^{1-\gamma}
\xi^{\frac{\alpha-\delta+1}{2}-\gamma}
\\
&\quad +a \sum_{i = 1}^{k}(\frac{|B_{i}|\|n_i\|}{\Gamma(
\frac{\alpha-\delta+1}{2}+\beta_i)})
\Big(\frac{1-\gamma}{{\frac{\alpha-\delta+1}{2}}+\beta_i-\gamma}\Big)^{1-\gamma}
\xi^{\frac{\alpha-\delta+1}{2}+\beta_i-\gamma} \Big]\Big\}
\|u-v\|\\
&\leq  \Big\{A|\|m\|\Big[
\frac{1}{\Gamma(\alpha)}\Big(\frac{1-\gamma}{\alpha-\gamma}\Big)^{1-\gamma}+
\frac{ |A_0|}{\Gamma (\alpha-\delta )}
\Big(\frac{1-\gamma}{\alpha-\delta -\gamma}\Big)^{1-\gamma}\\
&\quad  +\frac{a  |A_0|}{\Gamma (\frac{\alpha-\delta+1}{2}
)}\Big(\frac{1-\gamma}{\frac{\alpha-\delta+1}{2}-\gamma}\Big)^{1-\gamma}
\xi^{\frac{\alpha-\delta+1}{2}-\gamma} \Big]\\
&\quad +\sum_{i =
1}^{k}|B_{i}|\|n_i\|\Big[(\frac{1}{\Gamma( \alpha+\beta_i)})
\Big(\frac{1-\gamma}{\alpha+\beta_i -\gamma}\Big)^{1-\gamma}\\
&\quad +(\frac{|A_0|}{\Gamma( \alpha-\delta+\beta_i)})
\Big(\frac{1-\gamma}{\alpha-\delta +\beta_i
-\gamma}\Big)^{1-\gamma}\\
&\quad + (\frac{a|A_0|}{\Gamma(
\frac{\alpha-\delta+1}{2}+\beta_i)})
\Big(\frac{1-\gamma}{{\frac{\alpha-\delta+1}{2}}+\beta_i-\gamma}\Big)^{1-\gamma}
\xi^{\frac{\alpha-\delta+1}{2}+\beta_i-\gamma} \Big]\Big\}
\|u-v\|\\
&=[|A|\|m\| Z_1+\sum_{i = 1}^{k}|B_{i}|\|n_i\| Z_{i+1}]
\|u-v\|.
\end{align*}
By the condition (A3),  it follows that $\mathcal{T}$ is a
contraction mapping. Hence, by the Banach's fixed point theorem
$\mathcal{T}$ has a unique fixed point which is the unique
solution of the problem \eqref{1}. Then, the proof is complete.
\end{proof}

\section{Existence result via Leray-Schauder's alternative}

 In this section, by using the Leray-schauder's
alternative, we will find at least one solution to problem
\eqref{1}.
The proof of the main result in this section is  based on the
Leray-schauder's alternative \cite{Agarwal,Granas} that we
recall here for the reader's convenience.

\begin{lemma}\label{pjjj}
(Nonlinear alternative for single valued maps \cite{Agarwal,Granas}).
 Let $E$ be a Banach space, $C$ a closed, convex
subset of $E$, $U$ an open subset of $C$ and $0\in U$. Suppose
that $F$:\= {U}
$\to C$ is a completely continuous operator. Then, either
\begin{itemize}
\item[(i)] $F$ has a fixed point in \={U}, or
\item[(ii)] there is a $u\in \partial U$ (the boundary of $U$ in $C$) and
$\lambda\in (0,1)$ with $u=\lambda F(u)$.
\end{itemize}
\end{lemma}

We now state our main result in this section.

\begin{theorem}\label{thm3}
Suppose that $f,g_i:[0,1]\times \mathbb{R}\to \mathbb{R}$,
$i=1,\dots,k$,
are continuous functions. Assume that:
\begin{itemize}
\item[(H1)] There exist functions $p,p_i\in L^1 ([0,1], \mathbb{R}^+)$,
$i=1,\dots,k$, and nondecreasing functions $\psi,
\psi_i:\mathbb{R}^+ \to \mathbb{R}^+$, $i=1,\dots,k$,
such that
$$
|f(t,x)|\leq p(t) \psi(\|x\|),\;\;\;  |g_i(t,x)|\leq p_i(t) \psi_i(\|x\|),
$$
for all $(t,x)\in [0,1]\times \mathbb{R}$ and $i=1,\dots,k$.

\item[(H2)] There exists a constant $M>0$ such that
$$ 
\frac{M}{ |A| \psi(M)\|p\|_{L^1} \Omega + \sum_{i = 1}^{k} {| B_{i}| }
\Omega_i \psi_i(M)\|p_i\|_{L^1}}>1
$$
where
$$
\Omega= \frac{1} {\Gamma (\alpha+1 )}+ | A_0|\Big( \frac{1} {\Gamma
(\alpha-\delta+1 )}+ a \frac{\xi^{\frac{\alpha-\delta+1}{2}}}
{\Gamma (\frac{\alpha-\delta+1}{2}+1 )} \Big), 
$$ 
and
$$
\Omega_i= \frac{1}{\Gamma( \alpha+\beta_i+1)}
+|A_0| \Big(\frac{1}{\Gamma( \alpha-\delta +\beta_i+1)}+ a
\frac{\xi^{\frac{\alpha-\delta+1}{2}+\beta_i}}{\Gamma(
\frac{\alpha-\delta+1}{2}+\beta_i+1)}\Big),
$$
($i=1,\dots,k$).
\end{itemize}
Then, the boundary-value problem \eqref{1} has at least one
solution on $[0,1]$.
\end{theorem}

\begin{proof} 
Consider the operator $\mathcal{T}: \mathcal{C}\to \mathcal{C}$ with
\begin{align*}
&(\mathcal{T}u)(t)\\
&= - A \int_0^t \frac{{(t-s)}^{\alpha - 1}}
{\Gamma (\alpha )} f(s,u(s))ds  - \sum_{i = 1}^{k} { B_{i} }
\int_0^{t}
\frac{(t-s)^{\alpha+\beta_i - 1}}{\Gamma( \alpha+\beta_i)} g_i(s,u(s))ds \\
&\quad + t^{\alpha-1} A_0 \Big[ A \int_0^1
\frac{{(1-s)}^{\alpha-\delta - 1}} {\Gamma (\alpha-\delta )}
f(s,u(s))ds \\
&\quad +\sum_{i = 1}^{k} { B_{i} } \int_0^{1}
\frac{(1-s)^{\alpha-\delta +\beta_i - 1}}{\Gamma( \alpha-\delta
+\beta_i)} g_i(s,u(s))ds\\
&\quad -a A \int_0^\xi \frac{(\xi-s)^{\frac{\alpha-\delta-1}{2}}}
{\Gamma (\frac{\alpha-\delta+1}{2} )} f(s,u(s))ds  - a \sum_{i =
1}^{k} { B_{i} } \int_0^{\xi}
\frac{(\xi-s)^{\frac{\alpha-\delta-1}{2}+\beta_i}}{\Gamma(
\frac{\alpha-\delta+1}{2}+\beta_i)} g_i(s,u(s))ds \Big].
\end{align*}
We show that $\mathcal{T}$ maps bounded sets into bounded sets in
$C([0,1],\mathbb{R})$. for a positive number $r$, let 
$B_r=\{u\in C([0,1],\mathbb{R}):\|u\|\leq r\}$ be a bounded set in
$C([0,1],\mathbb{R})$. Then, we have
\begin{align*}
&|(\mathcal{T}u)(t)|\\
&\leq  |A|\int_0^t \frac{{(t-s)}^{\alpha - 1}} {\Gamma (\alpha )}
p(s) \psi(\|u\|)ds + \sum_{i = 1}^{k} { |B_{i}| } \int_0^{t}
\frac{(t-s)^{\alpha+\beta_i - 1}}{\Gamma( \alpha+\beta_i)} p_i(s) \psi_i(\|u\|)ds \\
&\quad  +  |A_0|t^{\alpha-1}\Big[ |A| \int_0^1
\frac{{(1-s)}^{\alpha-\delta - 1}} {\Gamma (\alpha-\delta )} p(s)
\psi(\|u\|) ds
\\
&\quad +\sum_{i = 1}^{k} {| B_{i}| } \int_0^{1}
\frac{(1-s)^{\alpha-\delta +\beta_i - 1}}{\Gamma( \alpha-\delta
+\beta_i)} p_i(s) \psi_i(\|u\|) ds \\
&\quad  +|A|a  \int_0^\xi
\frac{(\xi-s)^{\frac{\alpha-\delta-1}{2}}} {\Gamma
(\frac{\alpha-\delta+1}{2} )}p(s) \psi(\|u\|)ds
\\
&\quad +a \sum_{i = 1}^{k} { |B_{i}| } \int_0^{\xi}
\frac{(\xi-s)^{\frac{\alpha-\delta-1}{2}+\beta_i-1}}{\Gamma(
\frac{\alpha-\delta-1}{2}+\beta_i)} p_i(s) \psi_i(\|u\|) ds
\Big]\\
&\leq   |A| \psi(r)\|p\|_{L^1} \Big[ \frac{{t}^{\alpha}} {\Gamma
(\alpha+1 )}+ | A_0|t^{\alpha-1}\Big( \frac{1} {\Gamma
(\alpha-\delta+1 )}+ a \frac{\xi^{\frac{\alpha-\delta+1}{2}}}
{\Gamma (\frac{\alpha-\delta+1}{2}+1 )} \Big)
\Big]\\
&\quad + \sum_{i = 1}^{k} {| B_{i}|
}\psi_i(r)\|p_i\|_{L^1}\Big[ \frac{t^{\alpha+\beta_i}}{\Gamma(
\alpha+\beta_i+1)}  +|A_0| t^{\alpha-1}  \Big(\frac{1}{\Gamma(
\alpha-\delta +\beta_i+1)}\\
&\quad + a
\frac{\xi^{\frac{\alpha-\delta+1}{2}+\beta_i}}{\Gamma(
\frac{\alpha-\delta+1}{2}+\beta_i+1)}\Big)\Big].
\end{align*}
Consequently,
\begin{align*}
&\|\mathcal{T}u\|\\
&\leq   |A| \psi(r)\|p\|_{L^1} \Big[ \frac{1} {\Gamma (\alpha+1
)}+ | A_0|\Big( \frac{1} {\Gamma (\alpha-\delta+1 )}+ a
\frac{\xi^{\frac{\alpha-\delta+1}{2}}} {\Gamma
(\frac{\alpha-\delta+1}{2}+1 )} \Big) \Big]\\
&\quad +\sum_{i = 1}^{k} {| B_{i}| }\psi_i(r)\|p_i\|_{L^1}\Big[
\frac{1}{\Gamma( \alpha+\beta_i+1)} +|A_0| \Big(\frac{1}{\Gamma(
\alpha-\delta +\beta_i+1)}\\
&\quad + a \frac{\xi^{\frac{\alpha-\delta+1}{2}+\beta_i}}{\Gamma(
\frac{\alpha-\delta+1}{2}+\beta_i+1)}\Big)\Big]\\
&=|A| \psi(r)\|p\|_{L^1} \Omega+ \sum_{i = 1}^{k} {| B_{i}|
}\psi_i(r)\|p_i\|_{L^1}\Omega_i,
\end{align*}
let $K=|A| \psi(r)\|p\|_{L^1} \Omega+ \sum_{i = 1}^{k} {| B_{i}|
}\psi_i(r)\|p_i\|_{L^1}\Omega_i$, therefore, we conclude that
$\|\mathcal{T}u\|\leq K$. Thus,  $\mathcal{T}$ maps bounded sets
into bounded sets in $C([0,1],\mathbb{R})$.

Next, we show that $\mathcal{T}$ maps bounded sets into
equicontinuous sets of $C([0,1],\mathbb{R})$. Let $t_1,t_2\in
[0,1]$ with $t_1< t_2$ and $u\in B_r$; thus, we have
\begin{align*}
& |(\mathcal{T}u)(t_2)-(\mathcal{T}u)(t_1)|\\
&\leq   \frac{|A|}{\Gamma (\alpha )}  \int_0^{t_1}
[(t_2-s)^{\alpha - 1}-(t_1-s)^{\alpha -
1}] |f(s,u(s))|ds  \\
&\quad +\frac{|A|}{\Gamma (\alpha )}  \int_{t_1}^{t_2}
{(t_2-s)}^{\alpha - 1}
|f(s,u(s))|ds \\
&\quad +\sum_{i = 1}^{k} { \frac{|B_{i}|}{\Gamma(
\alpha+\beta_i)} } \int_0^{t_1}
[(t_2-s)^{\alpha+\beta_i - 1} -(t_1-s)^{\alpha+\beta_i - 1}]|g_i(s,u(s))|ds \\
&\quad +\sum_{i = 1}^{k} { \frac{|B_{i}|}{\Gamma(
\alpha+\beta_i)} } \int_{t_1}^{t_2}
(t_2-s)^{\alpha+\beta_i - 1} |g_i(s,u(s))|ds \\
&\quad + [(t_2)^{\alpha-1}-(t_1)^{\alpha-1}] |A_0| \Big[ |A|
\int_0^1 \frac{{(1-s)}^{\alpha-\delta - 1}} {\Gamma (\alpha-\delta
)}
|f(s,u(s))|ds \\
&\quad +\sum_{i = 1}^{k} { |B_{i}| } \int_0^{1}
\frac{(1-s)^{\alpha-\delta +\beta_i - 1}}{\Gamma( \alpha-\delta
+\beta_i)} |g_i(s,u(s))|ds \\
&\quad +a |A| \int_0^\xi
\frac{(\xi-s)^{\frac{\alpha-\delta-1}{2}}} {\Gamma
(\frac{\alpha-\delta+1}{2} )} |f(s,u(s))|ds  \\
&\quad +a \sum_{i = 1}^{k}
{ |B_{i}| } \int_0^{\xi}
\frac{(\xi-s)^{\frac{\alpha-\delta-1}{2}+\beta_i}}{\Gamma(
\frac{\alpha-\delta+1}{2}+\beta_i)} |g_i(s,u(s))|ds \Big]\\
&\leq   \frac{|A|}{\Gamma (\alpha )}  \int_0^{t_1}
[(t_2-s)^{\alpha - 1}-(t_1-s)^{\alpha -
1}] p(s) \psi(r) ds  \\
&\quad +\frac{|A|}{\Gamma (\alpha )}  \int_{t_1}^{t_2}
{(t_2-s)}^{\alpha - 1}
p(s) \psi(r)ds \\
&\quad +\sum_{i = 1}^{k} { \frac{|B_{i}|}{\Gamma(
\alpha+\beta_i)} } \int_0^{t_1}
[(t_2-s)^{\alpha+\beta_i - 1} -(t_1-s)^{\alpha+\beta_i - 1}]p_i(s) \psi_i(r)ds \\
&\quad +\sum_{i = 1}^{k} { \frac{|B_{i}|}{\Gamma(
\alpha+\beta_i)} } \int_{t_1}^{t_2}
(t_2-s)^{\alpha+\beta_i - 1} p_i(s) \psi_i(r)ds \\
&\quad + [(t_2)^{\alpha-1}-(t_1)^{\alpha-1}] |A_0| \Big[ |A|
\int_0^1 \frac{{(1-s)}^{\alpha-\delta - 1}} {\Gamma (\alpha-\delta
)} p(s) \psi(r)ds
\\
&\quad +\sum_{i = 1}^{k} { |B_{i}| } \int_0^{1}
\frac{(1-s)^{\alpha-\delta +\beta_i - 1}}{\Gamma( \alpha-\delta
+\beta_i)} p_i(s) \psi_i(r)ds \\
&\quad +a |A| \int_0^\xi
\frac{(\xi-s)^{\frac{\alpha-\delta-1}{2}}} {\Gamma
(\frac{\alpha-\delta+1}{2} )} p(s) \psi(r)ds  +a \sum_{i =
1}^{k} { |B_{i}| } \int_0^{\xi}
\frac{(\xi-s)^{\frac{\alpha-\delta-1}{2}+\beta_i}}{\Gamma(
\frac{\alpha-\delta+1}{2}+\beta_i)} p_i(s) \psi_i(r)ds \Big]
\end{align*}
Obviously, the right-hand side of the above inequality tends to
zero independently of $u\in B_r$ as $t_2 - t_1 \to 0$.
Therefore, $\mathcal{T} : C([0,1],\mathbb{R}) \to
C([0,1],\mathbb{R})$ is completely continuous by application of
the Arzel\'{a}-Ascoli theorem.

Now, we can conclude the result by using the Leray-Schauder's
nonlinear alternative theorem. Consider the equations 
$x=\lambda \mathcal{T} x$ for $\lambda\in (0,1)$ and assume that $u$ be a
solution. Then, using the computations in proving that
$\mathcal{T}$ is bounded, we have
\begin{align*}
\|u\|
&=\|\lambda (\mathcal{T}u)\|\\
&\leq  |A| \psi(\|u\|)\|p\|_{L^1}
\Big[ \frac{1} {\Gamma (\alpha+1 )}+ | A_0|\Big( \frac{1} {\Gamma
(\alpha-\delta+1 )}+ a \frac{\xi^{\frac{\alpha-\delta+1}{2}}}
{\Gamma (\frac{\alpha-\delta+1}{2}+1 )} \Big)
\Big]\\
&\quad + \sum_{i = 1}^{k} {| B_{i}|
}\psi_i(\|u\|)\|p_i\|_{L^1}\Big[ \frac{1}{\Gamma(
\alpha+\beta_i+1)} +|A_0| \Big(\frac{1}{\Gamma( \alpha-\delta
+\beta_i+1)}\\
&\quad + a\frac{\xi^{\frac{\alpha-\delta+1}{2}+\beta_i}}{\Gamma(
\frac{\alpha-\delta+1}{2}+\beta_i+1)}\Big)\Big];
\end{align*}
therefore,
$$
\frac{\|u\|}{|A| \psi(\|u\|)\|p\|_{L^1} \Omega 
+ \sum_{i = 1}^{k} {| B_{i}| }\Omega_i
\psi_i(\|u\|)\|p_i\|_{L^1}}\leq 1.
$$ 
In view of (H2), there exists $M$ such that $\|u\|\neq M$. Let us set
$$
U=\{x\in  C([0,1],\mathbb{R}): \|x\| <M\}.
$$
It is obvious that the operator $\mathcal{T} : \bar {U} \to C([0,1],\mathbb{R})$ 
is continuous and completely continuous. From
the choice of $U$ there is no $u \in \partial U$ such that
$u=\lambda \mathcal{T}(u)$ for some $\lambda \in (0,1)$.
Therefore, by the Leray-Schauder's nonlinear alternative theorem
(Lemma \ref{pjjj}), we conclude that $\mathcal{T}$ has a fixed
point $u\in$ \={U} which is a solution of the problem \eqref{1}.
Thus, the proof is completed. 
\end{proof}

\section{Application}
\begin{example} \rm
Consider the  singular boundary value problem
\begin{equation}\label{rrrr}
\begin{gathered}
    - D^{3/2} u(t) = A f (t, u (t))+\sum_{i=1}^3 B_i I^{\beta_i} g_i (t, u(t)) ,
    \quad    t \in (0, 1),\\
    D^{1/4} u (0) = 0,\quad  D^{1/4} u (1) = a D^{1/8}(D^{1/4} u(t))\big|_{t=1/2}
\end{gathered}
\end{equation}
Here, $A= B_i=1$, $(i=1,2,3)$, $\beta_1=1/2$,
$\beta_2=1/3$, $\beta_3=2/3$, $a= 2$, $f(t,u)=\frac{9}{125} \sqrt{1-t}(1+u)$, 
$g_i(t,u)=\frac{3}{29}\tan^{-1} u+\cos(e^t)$. 
With the given data, we obtain:
$$
A_0=\frac{\Gamma(\alpha-\delta)
\Gamma(\frac{\alpha-\delta+1}{2})}{\Gamma(\alpha)
\Big(\Gamma(\frac{\alpha-\delta+1}{2})-a\Gamma(\alpha-\delta)
\xi^{\frac{\alpha-\delta-1}{2}}\Big)}=-1.3365,
$$
\begin{align*}
\Delta&= \sup_{t\in [0,1]} \Big\{ |A|\Big[ \frac{{t}^{\alpha}}
{\Gamma (\alpha+1 )}+ | A_0|t^{\alpha-1}\Big( \frac{1} {\Gamma
(\alpha-\delta+1 )}+ a \frac{\xi^{\frac{\alpha-\delta+1}{2}}}
{\Gamma (\frac{\alpha-\delta+1}{2}+1 )} \Big) \Big]\\
&\quad +\sum_{i = 1}^{k} {| B_{i}| }\Big[
\frac{t^{\alpha+\beta_i}}{\Gamma( \alpha+\beta_i+1)}  +|A_0|
t^{\alpha-1}  \Big(\frac{1}{\Gamma( \alpha-\delta +\beta_i+1)}\\
&\quad + a \frac{\xi^{\frac{\alpha-\delta+1}{2}+\beta_i}}{\Gamma(
\frac{\alpha-\delta+1}{2}+\beta_i+1)}\Big)\Big]\Big\}
= 8.9046,
\end{align*}
and $L_1=9/125$, $L_2=L_3=L_4=3/29$ as 
$|f(t,u)-f(t,v)|\leq \frac{9}{125} |u-v|$, 
$|g_i(t,u)-g_i(t,v)|\leq \frac{3}{29} |u-v|$. Obviously, 
$L=\max\{L_i:i=1,\dots,4\}=3/29$ and $L<\frac{1}{\Delta}$. 
Hence, all the assumptions of Theorem \ref{thm1} are satisfied.
Thus, by the conclusion of Theorem  \ref{thm1},  problem \eqref{rrrr} has a unique
solution.
\end{example}


\subsection*{Acknowledgments}
The authors would like to thank the anonymous referees for their suggestions
and helpful comments which improved the presentation of the
original manuscript.

\begin{thebibliography}{99}


\bibitem{Agarwal} R.\ P.\ Agarwal, M. \ Meehan, D. \ Oregan;
\emph{Fixed Point Theory and Applications},  Cambridje
University Press, Cambridje, (2001).

\bibitem{Babakhani} A.\ Babakhani, V.\ D.\ Gejji;
\emph{Existence of positive solutions of nonlinear fractional
differential equations}, J. Math. Anal. Appl. 278 (2003) 434-442.

\bibitem{Bai} Z.\ B.\ Bai, H.\ S.\ L\"{u};
\emph{Positive solutions for boundary value problem of nonlinear
fractional differential equation}, J. Math. Anal. Appl. 311 (2005)
495-505.

\bibitem{Delbosco} D.\ Delbosco, L.\ Rodino;
\emph{Existence and uniqueness for a nonlinear fractional
differential equation}, J. Math. Anal. Appl. 204 (1996) 609-625.

\bibitem{Diethelm} K.\ Diethelm, A.\ D.\ Freed;
\emph{On the solution of nonlinear fractional order differential
equations used in the modeling of viscoplasticity},
in:F. Keil,W. Mackens, H. voss, J. Werther(Eds.), Scientific Computing
in Chemical Engineering II-Computational Fluid Dynamics, Reaction
Engineering and Molecular
Properties, Springer-Verlag, Heidelberg,1999.

\bibitem{Gaul} L.\ Gaul, P.\ Klein, S.\ Kemple;
\emph{Damping description involving fractional operators}, Mech.
Syst. Signal Process 5 (1991) 81-88.

\bibitem{Glockle} W.\ G.\ Glockle, T.\ F.\ Nonnenmacher;
\emph{A fractional calculus approach to self-semilar protein
dynamics}, Biophys. J. 68 (1995) 46-53.

\bibitem{Granas} A.\ Granas, R.\ B.\ Guenther, J.\ W.\ Lee;
\emph{Some general existence principle in the Caratheodory theory
of nonlinear systems}, J. Math. Pures Appl. 70 (1991) 153-196.

\bibitem{Hussein} Hussein.\ A.\ H.\ Salem;
\emph{On the fractional order m-point boundary value problem in
reflexive Banach spaces and Weak topologies}, J. Comput. Appl.
Math. 224( 2009) 565-572.

\bibitem{Kilbas1} A.\ A.\ Kilbas, J.\ J.\ Trujillo;
\emph{Differential equations of fractional order: Methods, results
and problems I}, Appl. Anal. 78 (2001) 153-192.

\bibitem{Kilbas2} A.\ A.\ Kilbas, J.\ J.\ Trujillo;
\emph{Differential equations of fractional order: Methods, results
and problems II}, Appl. Anal. 81 (2002) 435-493.

\bibitem{Kilbas3} A.\ A.\ Kilbas, H.\ M.\ Srivastava, J.\ J.\ Trujillo;
\emph{Theory and Applications of Fractional Differential
Equations}, Elsevier, Amsterdam, 2006.

\bibitem{Li} C.\ F.\ Li, X.\ N.\ Luo, Y.\ Zhou;
\emph{Existence of positive solutions of the boundary value
problem for nonlinear fractional differential equations}, Comput.
Math. Apll. 59 (2010) 1363-1375.

\bibitem{Mainardi} F.\ Mainardi;
\emph{Fractional calculus: some basic problems in continuum and
statistical mechanics}, in: A.Carpinteri, Mainardi(Eds.), Fractals
and Fractional calculus in continuum mechanics, Springer-Verlag,
New York, 1997 .

\bibitem{Metzler} R.\ Metzler, W.\ Schick, H.\ G.\ Kilian, T.\ F.\ Nonnenmacher;
\emph{Relaxation in filled polymers: a fractional calculus
approach}, J. Chem. Phys. 103 (1995) 7180-7186.

\bibitem{Podlubny} I.\ Podlubny;
\emph{Fractional Differential Equations}, Academic Press, New
York, 1999.

\bibitem{Samko} G.\ Samko, A.\ Kilbas, O.\ Marichev;
\emph{Fractional Integrals and Derivatives: Theory and
Applications}, Gordon and Breach, Amsterdam, 1993.

\bibitem{Scher} H.\ Scher, E.\ W.\ Montroll;
\emph{Anomalous transit-time dispersion in amorphous solids},
Phys. Rev. B 12 (1975) 2455-2477.

\end{thebibliography}

\end{document}
