Seth F. Oppenheimer, Ruping Fan, Stephan Pruett
Abstract:
The purpose of this paper is to develop a model for the activation of the
gene responsible for the production of the cytokine interleukin 6, IL-6.
This is motivated by experimental work that indicates that exposure to
certain exogenous chemicals results in changes in cytokine production. In
particular, exposure to both the widely used pesticide atrazine and the
legacy pesticide dieldrin, still very much present in the environment,
resulted in the reduction of the production of IL-6. We develop of model
of twelve ordinary differential equations to model the effect of changes in
transcription factor levels on IL-6 production rates and establish basic
qualitative properties of solutions.
Published April 15, 2009.
Math Subject Classifications: 92C17, 34A12.
Key Words: Gene activation; neurotoxons.
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Seth F. Oppenheimer Department of Mathematics and Statistics Drawer MA, Mississippi State University, MS 39762, USA e-mail: seth@math.msstate.edu |
| Ruping Fan Department of Cellular Biology and Anatomy Louisiana State University Health Science Center 1501 Kings Highway, Shreveport, LA 71130, USA | |
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Stephan Pruett CVM Basic Science Department, Mississippi State University PO box 6100, Mississippi State, MS 39762, USA email: sbp7@msstate.edu |
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