Third International Conference on Applications of Mathematics to Nonlinear Sciences.
Electron. J. Diff. Eqns., Conference 27 (2024), pp. 75-95.

Impact of vaccination and sterilization on the transmission dynamics of rabies

Vijai Shanker Verma, Laxman Bahadur Kunwar

Abstract:
We have constructed a mathematical model by dividing the dog and human populations into eight compartments as the rabies virus is likely to spread in both populations. In the model, disease-controlling strategies such as vaccination, sterilization and culling are taken into consideration, and their impact is studied. The current study assumes that dogs can transmit rabies among dogs as well as to human population. We have applied the next-generation matrix technique to compute the basic reproduction number. Also, each parameters involved are subjected to sensitivity analysis using the approach of normalized sensitivity index. The disease-free (or rabies-free) and endemic-equilibrium points are discovered analytically. The endemic equilibrium point is shown to be locally asymptotically stable. The numerical simulations, which use approximations for parameter values, shows that effective method for controlling rabies transmission is a combination of vaccination, sterilization and culling of infected dogs. The findings indicate that the annual dog birth rate is also a critical factor in affecting the rabies virus spread.

Published August 20, 2024.
Math Subject Classifications: 92B05.
Key Words: Equilibrium point; basic reproduction number; stability; next-generation matrix; vaccination; existence of solutions.
DOI: 10.58997/ejde.conf.27.v1

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Vijai Shanker Verma
Department of Mathematics and Statistics
Deen Dayal Upadhyaya Gorakhpur University, India
email: vsverma.mathstat@ddugu.ac.in
Laxman Bahadur Kunwar
Department of Mathematics
Thakur Ram Multiple Campus
Tribhuvan University, Birgunj, Nepal
email: laxman.kunwar@trmc.tu.edu.np

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