Electron. J. Differential Equations, Vol. 2026 (2026), No. 68, pp. 1-29.

Global well-posedness and invariant regions for a one-dimensional RD-ARD glioblastoma model

Zhipeng Yang, Zhenyu Zhan

Abstract:
We study a one-dimensional reaction-diffusion and advection-reaction-diffusion system arising from a heterogeneous glioblastoma model with shared crowding effects. The two components represent latent subpopulation densities that both diffuse and proliferate; the second is additionally subject to a constant advective bias, with crowding coupled through the total density. On a bounded interval, under either componentwise Neumann conditions or the natural zero-flux condition for the advective component, we establish a global well-posedness theory, positivity preservation, invariant regions, and uniform absorbing bounds in the supremum norm. Under the zero-flux condition, the invariant and absorbing upper barriers for the second component carry the exponential spatial weight \(e^{(a/ D_v)x}\), in contrast to the constant barriers available under componentwise Neumann conditions. We further formulate the associated semiflow and prove the existence of a global attractor.

Submitted June 25 2026. Published September 9, 2026.
Math Subject Classifications: 35K57, 35B40, 92C50.
Key Words: Reaction-diffusion-advection system; glioblastoma model; global well-posedness.
DOI: 10.58997/ejde.2026.68

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Zhipeng Yang
Department of Mathematics
Yunnan Normal University, Kunming, China
email: yangzhipeng326@163.com
Zhenyu Zhan
Department of Mathematics
Yunnan Normal University, Kunming, China
email: 20972850@qq.com

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